GENOME-WIDE ASSOCIATION STUDY IMPLICATES NOVEL LOCI AND REVEALS CANDIDATE EFFECTOR GENES FOR LONGITUDINAL PEDIATRIC BONE ACCRUAL

Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual

Abstract Background Bone accrual impacts lifelong skeletal health, but genetic discovery has been primarily limited to cross-sectional study designs and hampered by uncertainty about target effector genes.Here, we capture this dynamic phenotype by modeling longitudinal bone accrual across 11,000 bone scans in a cohort of healthy children and adoles

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HPAStainR: a Bioconductor and Shiny app to query protein expression patterns in the Human Protein Atlas [version 2; peer review: 1 approved, 2 approved with reservations]

The Human Protein Atlas is a website of protein expression in human tissues.It is an excellent resource of tissue and cell type protein localization, but only allows the query of a single protein at a time.We introduce HPAStainR as a new Shiny app and Bioconductor/R package used to query the scored staining patterns in the Human Protein Atlas with

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Nerve Dependence in Colorectal Cancer

Cancerous invasion of nerves has been reported in a list of malignant tumors as a high-risk pathological feature and marker of poor disease outcome especially in neurotrophic cancers (such as in pancreas and prostate), indicating that although once neglected, nerves could have played a pivotal role in tumorigenesis and cancer progression.In colorec

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Banning is not enough: The complexities of oceanic shark management by tuna regional fisheries management organizations

Recently, declining populations of several pelagic shark species have led to global conservation concerns surrounding this group.As a result, a series of species-specific banning measures have been implemented by Regional Fishery Management Organizations (RFMOs) in charge of tuna fisheries, which include retention bans, finning bans and trading ban

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